Targeting Diet-Microbiome Interactions in the Pathogenesis of Parkinsons Disease
Abstract
The current project will analyze the gut microbiome and metabolites from PD patients and controls, and employ clinically relevant mouse models to determine how metabolites produced by the microbiome from dietary substrates affect motor symptoms. We propose to test whether directly regulating microbial metabolite profiles using designer dietary fibers and probiotics offers new avenues for ameliorating PD-like symptoms.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2018
- Accession Number
- AD1070372
Entities
People
- Viviana Gradinaru
Organizations
- California Institute of Technology