Synthesis and Acetylcholinesterase Assay Report for RS182A and RS150D
Abstract
The synthesis and the reactivation kinetics of two cholinergic reactivators, RS150D and RS182A, are reported, and the results are compared to the kinetics of the standard reactivator, 2-pyridine aldoxime methyl chloride (2-PAM). In a 2011 article, Sit and his coworkers highlighted RS150D as a promising reactivator of ethyl N,N-dimethyl phosphoramidocyanidate (GA)-inhibited acetylcholinesterase (AChE), although it was not found to perform better than the standard 2-PAM reactivator. The reaction schemes for RS150D and RS182A are described, and the kinetic assays with several agents are reported. The synthesis produced acceptable overall yields.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 31, 2018
- Accession Number
- AD1070683
Entities
People
- Andrew J. Walz
- James Myslinski
- Jude Height
Organizations
- Edgewood Chemical Biological Center