Biological Characterization and Clinical Utilization of Metastatic Prostate Cancer Associated lincRNA SChLAP1

Abstract

Long non-coding RNAs (lincRNAs) are polyadenylated RNA species that are more than 200bp in length and are implicated in development of variety of cancers including prostate cancer. In this study we have investigated the precise interaction between SChLAP1 and SWI/SNF complex components, furthermore studied the effects of SChLAP1 on genome-wide nucleosome occupancy and H3K27Me3 in metastatic prostate cancer. Finally, we have determined the potential clinical utility of targeting SChLAP1, SChLAP1-SWI/SNF interaction and/or downstream effectors as a treatment modality in metastatic prostate cancer, and found that co-targeting Androgen Receptor (AR) and Enhancer of zeste homolog 2 (EZH2) as a promising strategy for treatment of CRPC.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1071680

Entities

People

  • Lanbo Xiao

Organizations

  • Board of Regents of the University of Michigan

Tags

DTIC Thesaurus Topics

  • Chemistry
  • Computational Science
  • Computer Science
  • Data Mining
  • Data Science
  • Databases
  • Gene Expression
  • Genetics
  • Health Services
  • Information Processing
  • Information Science
  • Knowledge Management
  • Medical Personnel
  • Neoplasms
  • Network Science
  • Oncology
  • Surveys

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Prostate Cancer Biology.