Targeting Diet-Microbiome Interactions in the Pathogenesis of Parkinson's Disease

Abstract

The current project will analyze the gut microbiome and metabolites from PD patients and controls, and employ clinically relevant mouse models to determine how metabolites produced by the microbiome from dietary substrates affect motor symptoms. We propose to test whether directly regulating microbial metabolite profiles using designer dietary fibers and probiotics offers new avenues for ameliorating PD-like symptoms.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2018
Accession Number
AD1071685

Entities

People

  • Sarkis Mazmanian

Organizations

  • California Institute of Technology

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Butyrates
  • California
  • Diseases And Disorders
  • Electronic Mail
  • Fatty Acids
  • Gut Microbiome
  • Medical Personnel
  • Metabolites
  • Microbiomes
  • Parkinson'S Disease
  • Pathogenesis
  • Probiotics
  • Students
  • Substrates
  • Targeting
  • Trainees

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.

Technology Areas

  • Biotechnology