Role of a Novel Family of Short RNAs, tRFs, in Prostate Cancer

Abstract

tRNA derived fragments, tRFs are a novel class of small RNA which are shown to function by associating to Argonaute proteins. Unlike microRNA, the biogenesis of tRFs is independent of Dicer and Drosha enzymes. Upon meta-analysis of more than 50 small RNA-seq data of different species and cell lines we have previously shown the presence of fragments generated from both 5 and 3 end of the tRNA and called them as tRF-5 and tRF-3, respectively. We are now interested in mining TCGA prostate cancer patients data to identify tRFs and predict potential targets involved in prostate cancer cell migration and proliferation.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2018
Accession Number
AD1071902

Entities

People

  • Manjari Kiran

Organizations

  • University of Virginia

Tags

DTIC Thesaurus Topics

  • Carcinoma
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Gene Expression
  • Genetics
  • Lymphatic Diseases
  • Medical Personnel
  • Proteins
  • Rna Stability
  • Stem Cells

Fields of Study

  • Biology

Readers

  • Materials Science and Engineering.
  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.