Implantation of Full-Thickness Skin Columns to Decrease Hypertrophic Scar Formation After Deep Partial Thickness Burns
Abstract
The purpose of this study is to provide proof-of-concept, pre-clinical evidence for use of autologous full-thickness skin column implantation for the treatment of deep partial-thickness burn injury to prevent hypertrophic scar formation. This evidence will support a pivot into clinical trials of this strategy. The long-term objective is to develop autologous full-thickness skin column implantation as an improved, low-morbidity methodology for the treatment of deep partial-thickness burn. The scientific objective of this proposal is to evaluate the early (pre-epithelialization) and late (post-epithelialization) efficacy of three different seeding ratios of implanted full-thickness skin columns in reducing hypertrophic scar formation by accelerating wound closure, improving skin quality parameters, reducing wound contraction and minimizing donor-site morbidity in a porcine model of deep partial thickness burn.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2018
- Accession Number
- AD1072005
Entities
People
- Anders H Carlsson
- Rodney K Chan