Tissue-Engineered Cancer Metastasis to Improve the Abscopal Effect and Cancer Immunotherapy in Melanoma
Abstract
Our application aims to address the PRCRP topic area melanoma and other skin cancers and the Military Relevance FocusArea of Gaps in cancer treatment that may affect the general population but have a particularly profound impact on the health and wellbeingof military members, Veterans, and their beneficiaries. Cancer immunotherapy has been shown to be an exciting new treatment formelanoma. There has been high interest in the development of approaches that can further improve cancer immunotherapy. Radiotherapy(radiosurgery) has shown to be synergistic with immunotherapy and can lead to abscopal effect. However, not every patient is eligible forradiosurgery and the treatment can lead to significant side effects. The key objective of this application is to improve cancer immunotherapy for melanoma using novel tissue engineered cancer metastasis models and the abscopal effect. We hypothesize that we can induce a robust abscopal effect by engineering cancer metastasis ex vivo and administering lethal radiotherapy prior to in vivo administration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2018
- Accession Number
- AD1072015
Entities
People
- Zhuang A. Wang
Organizations
- University of North Carolina at Chapel Hill