Increasing Bone Mass and Bone Strength in Individuals with Chronic Spinal Cord Injury: Maximizing Response to Therapy
Abstract
The overall objective of this research is to determine the optimal approach to enhancing and maintaining bone mass and bone strength in people with chronic SCI. Our previous research showed that teriparatide treatment can result in an increase in bone mass in people with SCI. We hypothesize that initiating a subsequent one year of treatment with alendronate will result in a further increase in bone mass and bone strength. In this study, participants terminating 2 years of teriparatide therapy are treated with open-label oral alendronate for one year. All participants are evaluated with bone imaging (DXA and CT scanning) and serum bone markers at 6 monthly intervals during the course of the study. Correlation of BMD and bone strength with fracture prevalence and incidence will also be undertaken in order to define a fracture threshold. 17 participants have been entered into this study; all have completed one year of treatment. All data have been recorded and entered. Analysis is ongoing. Bone strength testing has been initiated and data collection is on-going.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2018
- Accession Number
- AD1072023
Entities
People
- Thomas J Schnitzer
Organizations
- Northwestern University