Translation of a Physiologically Based Pharmacokinetic Model Used to Develop Health Protective Levels for Trichloroethylene
Abstract
Trichloroethylene (TCE) was commonly used as a solvent by the Department of Defense, as well at private sector facilities. Releases to the environment from its past use make TCE one of the most common contaminants encountered at hazardous waste sites. The Air Force Research Laboratory previously worked with the U.S. Environmental Protection Agency to develop a harmonized physiologically based pharmacokinetic model for TCE; the model was updated by the Environmental Protection Agency for their use in their toxicological review. In a previous effort, initial work was done to evaluate this model. Follow-on funding was later obtained to address some of the issues noted in the previous work and to provide modeling support in the completion of a risk assessment for TCE. This new work involved the following tasks: 1) adding code to the model to ensure mass balance in tissue blood flows and volumes; 2) modify/edit the code to resolve instability in the model; 3) regenerate the validation figures and re-run the sensitivity analysis; 4) use the model to predict dose metrics for relevant endpoints for occupational exposure limit determination for specific predetermined oral and inhalation studies; and 5) develop deliverables describing the methods used and the outcomes of each of these tasks. The methods used to complete these tasks and the resulting findings are presented in this report.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 12, 2019
- Accession Number
- AD1072649
Entities
People
- Darrin K. Ott
- David R. Mattie
- Heather A. Pangburn
- Jeffery M. Gearhart
- Tammie R. Covington
- Teresa R Sterner
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- United States Air Force School of Aerospace Medicine