Molecular Cross-Talk: Bone Metastatic Prostate Cancer and Nociceptive Neurons
Abstract
The goal of this project is to determine the roles of angiotensin II and its receptor in prostate cancer induced bone pain and bone metastatic growth. Aim 1 will provide the framework to identify the extent to which the interaction between cancer cells and nociceptive neurons through the angiotensin II and receptor axis affects cancer-induced bone pain. Aim 2 will determine the downstream molecular mechanisms whereby angiotensin II and its receptor axis affects bone pain. Aim 3 will define how nociceptive neuron influence tumor outgrowth. We believe that the insights derived from our investigations will lead to new strategies for reducing cancer-induced bone pain and also the outgrowth of bone metastasis. During this period, we found that prostate cancer (PCa) enhances the sprouting of calcitonin gene-related peptide (CGRP)- expressing sensory nerves both in vitro and in vivo. We also found that the CGRP/its receptor axis controls PCa bone metastatic progression in vitro and human. In addition, we developed the technique to downregulate CGRP expression in mouse nerves that enables us to test effects of CGRP on PCa progression in animals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2018
- Accession Number
- AD1073039
Entities
People
- Christopher Peters
- Yusuke Shiozawa
Organizations
- Wake Forest University