Molecular Cross-Talk: Bone Metastatic Prostate Cancer and Nociceptive Neurons

Abstract

The goal of this project is to determine the roles of angiotensin II and its receptor in prostate cancer induced bone pain and bone metastatic growth. Aim 1 will provide the framework to identify the extent to which the interaction between cancer cells and nociceptive neurons through the angiotensin II and receptor axis affects cancer-induced bone pain. Aim 2 will determine the downstream molecular mechanisms whereby angiotensin II and its receptor axis affects bone pain. Aim 3 will define how nociceptive neuron influence tumor outgrowth. We believe that the insights derived from our investigations will lead to new strategies for reducing cancer-induced bone pain and also the outgrowth of bone metastasis.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2018
Accession Number
AD1073041

Entities

People

  • Christopher Peters
  • Yusuke Shiozawa

Organizations

  • Wake Forest University

Tags

DTIC Thesaurus Topics

  • Bone And Bones
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Medical Personnel
  • Orthopedics
  • Pain
  • Peptide Growth Factors
  • Peptides
  • Proteins

Fields of Study

  • Medicine

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