Intranasal Insulin for Improving Cognitive Function in Multiple Sclerosis
Abstract
Cognitive impairment is common in and devastating to people with multiple sclerosis (MS). MS is a common, chronic, central nervous system (CNS) disease characterized by inflammation, demyelination, and neurodegeneration. One of the most devastating symptoms of this disease is impaired cognitive function, which is common and present in over 60% of individuals with MS. Attention, memory, executive functioning, and especially processing speed are cognition areas negatively affected by MS. Intranasal insulin has been shown to help alleviate some cognitive impairment in other neurodegenerative diseases like MS. Insulin is critical for helping with regulation of multiple CNS functions including brain metabolism, learning and memory. Insulin is present at high levels in the brain and when these levels are decreased, there may be learning and memory impairments. Moreover, insulins anti-inflammatory effects may also impact brain health via suppressing molecules that may provoke ongoing CNS inflammation and damage in disease states. This clinical trial is designed to evaluate the safety and tolerability of intranasal insulin in people with MS. In addition, this trial is going to evaluate if intranasal insulin improves cognition in people with MS, as assessed by standardized cognitive assessment tests.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2018
- Accession Number
- AD1073044
Entities
People
- Ama Avornu
- Ellen M Mowry
- Pablo Ravenna
- Scott Newsome
Organizations
- Johns Hopkins University