Prostate Cancer Grade Mapping with Transrectal Electrical Impedance Tomography
Abstract
The primary objective of this research is to combine advanced integrated electronics with transrectal electrical impedance tomography (TREIT) and electrical impedance sensing biopsy (EIS-Bx) devices to improve TRUS-guided prostate biopsy procedures and help to address the challenge of distinguishing aggressive from indolent disease in men newly diagnosed with prostate cancer. The novelty in this program falls into two categories: 1) we aim to couple our single point EIS-Bx measurement device with an array of electrodes adhered to a standard end-fired TRUS probe (Halters team) and 2) we aim to develop a custom application specific integrated circuit (ASIC) that will enable us to measure these electrical properties over a wide frequency range (optimal for discriminating high from low-grade prostate cancer) and at high frame rates (required for real-time prostate biopsy procedures) (Odames team). During the first two years of this study, we focused on designing, implementing and validating (1) a small form-factor EIT based on a custom ASIC chip (2) an EM-tracking approach to capture the surface of the prostate during TRUS, (3) finite element method meshing approaches and reconstruction algorithms for imaging the electrical properties of prostate during an TREIT + EIS-Bx procedure. Year 3 focused on further phantom studies and the development of a second version (20-channel) of a minaturized EIT system. A no-cost-extension period of Year 4 will focus on clinical data acquisition from a series of ex vivo human prostates.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2018
- Accession Number
- AD1073049
Entities
People
- Kofi Odame
- Ryan Halter
Organizations
- Dartmouth College