Targeting Quiescence in Prostate Cancer
Abstract
A major problem in prostate cancer is finding and eliminating the non-proliferating or quiescent cancer cells. This is because early in prostate cancer, a small number of cancer cells metastasize to other tissues such as the bone, where they can lay dormant for years. Most chemotherapies target actively dividing cancer cells causing primary tumor shrinkage, but leave behind quiescent cancer cells which may seed new, more aggressive and chemo-resistant cancers at a later date. During this second year of funding, we have discovered that PCa cells that metastasize to the bone exhibit dramatically different cell cycle characteristics from those in the liver, suggesting signals from the bone are key to regulating PCa cell cycle and dormancy. We therefore tested signals from the marrow environment and determined how they influence the proliferation vs. quiescence decision in PCa cells. During the no cost extension period we are continuing experiment to examine how these signals may modulate the effect of chemotherapies on PCa cell cycle regulation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2018
- Accession Number
- AD1074217
Entities
People
- Laura Buttitta
Organizations
- Board of Regents of the University of Michigan