Analysis of Serum Concentrations of Tranexamic Acid Given by the Intramuscular Route in a Swine (Sus scrofa) Hemorrhage Model
Abstract
Objectives: Tranexamic acid (TXA) improves survival in traumatic hemorrhage. We hypothesized that IM and IV administration have similar pharmacokinetics and ability to reverse in vitro hyperfibrinolysis in a swine controlled hemorrhage model. Methods: Twelve Yorkshire cross swine were anesthetized, instrumented, and subjected to a 35 percent controlled hemorrhage, followed by resuscitation. They were randomized to receive a 1 g IV TXA infusion over 10 minutes or 1 g lM TXA in two 5 ml injections. Serum TXA concentrations were determined using liquid chromatography-mass spectrometry. Results: All animals achieved class Ill shock. There was no difference in the concentration-time areas under the curve (AUC) between TXA given by either route. The absolute bioavailability of IM TXA was 97 percent. Conclusion: The pharmacokinetics of IM TXA were similar to IV TXA during hemorrhagic shock in our swine model. There was no difference in total body exposure to equal doses of TXA between the two routes of administration. IM TXA may prove beneficial in scenarios where difficulty establishing dedicated IV access could otherwise limit or delay its use.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 07, 2019
- Accession Number
- AD1077367
Entities
People
- Marguerite Spruce
Organizations
- David Grant USAF Medical Center