Toxicology Assessment of IMX-104, January 2019
Abstract
This report summarizes the available toxicological information for the insensitive munition IMX-104 and its components, dinitroanisole (DNAN), 3-nitro-1,2,4-triazol-5-one (NTO), and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). The toxicity of the IMX-104 mixture is unknown in mammalian models. In aquatic species, acute mixture effects of IMX-104 were species dependent while sublethal effects were largely due to DNAN. DNAN and RDX demonstrate moderate oral toxicity while the oral toxicity of NTO is low. Toxic effects of DNAN are consistent with other nitroaromatics, including the development of anemia. Testicular toxicity is the predominant effect of exposure to NTO, while neurotoxicity and carcinogenesis are associated with exposure to RDX. NTO demonstrates minimal ecotoxicity. DNAN and RDX demonstrate greater ecotoxicity, particularly in mammals and birds.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2019
- Accession Number
- AD1077650
Entities
People
- Emily M. Lent
Organizations
- United States Army Center for Health Promotion and Preventive Medicine