Toxicology Assessment of IMX 101-Update

Abstract

This report summarizes the available toxicological information for the insensitive munition IMX-101 and its components, dinitroanisole (DNAN), 3-nitro-1,2,4-triazol-5-one (NTO), and nitroguanidine (NQ). The toxicity of the IMX-101 mixture is largely unknown, however, a single subacute test in rats suggests greater than additive mixture effects. In aquatic species, mixture effects of IMX-101 largely due to DNAN. NTO and NQ demonstrate limited oral toxicity while the oral toxicity of DNAN is moderate. Toxic effects of DNAN are consistent with other nitroaromatics, including the development of anemia. Testicular toxicity is the predominant effect of exposure to NTO. Exposure to NQ induces minimal, non-specific signs of toxicity. NTO demonstrates minimal ecotoxicity. DNAN demonstrates greater ecotoxicity, particularly in mammals and birds. Ecotoxicity of NQ is low; however, photodegradation products of NQ demonstrate increased aquatic toxicity.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2019
Accession Number
AD1077652

Entities

People

  • Emily M. Lent

Organizations

  • United States Army Center for Health Promotion and Preventive Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Birds
  • Body Weight
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Fish
  • Health Services
  • Insensitive Explosives
  • Medical Personnel

Fields of Study

  • Environmental science

Readers

  • Agricultural Chemistry/Soil Science
  • Toxicology/Environmental Toxicology