Protection from Neuronal Cell Death Caused by Global Cerebral Ischemia Induced by Cardiac Arrest Followed by Cardiopulmonary Resuscitation in Swine (Sus scrofa)

Abstract

The purpose of this study was to evaluate the effects of compound tatCN19o in post cardiac arrest GCI in swine measured via 24 observations 72 hour post injury global and microscopic neurohistopathology. Quality of life post cardiac arrest was measured using the neurological severity score (NSS) over a 72 hour period of observation. Mean arterial blood pressure at 60 minutes, lactate, and base excess, were also measured as secondary outcomes as well as potential biological markers for GCI (Neuron specific enolase, S100B and glial fibrillary acidic protein levels).

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Document Details

Document Type
Technical Report
Publication Date
Apr 25, 2018
Accession Number
AD1078817

Entities

People

  • Joseph K Maddry

Organizations

  • 59th Medical Wing

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Air Force
  • Anesthesia
  • Biological Markers
  • Cardiac Arrest
  • Cardiopulmonary Resuscitation
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Cell Physiological Processes
  • Cerebrovascular Disorders
  • Compression
  • Diseases And Disorders
  • Electric Stimulation Therapy
  • Emergencies
  • Emergency Treatment
  • Health Services
  • Ischemia
  • Medical Personnel
  • Observation
  • Quality Of Life
  • Resuscitation
  • Therapy

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Molecular Genetics
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