Chronic Toxicity Test in Rats Exposed to 3-Nitro 1,2,4-Triazol-5-One (NTO) in Drinking Water

Abstract

To evaluate the effects of chronic exposure to NTO, male and female rats were given ad libitum access to NTO in drinking water at concentrations of 0, 36, 110, 360, 1100, and 3600 mg/l for one year. NTO was generally non-toxic in females at the doses tested. Toxicity in males was limited to testicular toxicity as demonstrated in previous studies. Chronic exposure did not result in testicular toxicity at lower doses and the toxicity observed only in the high dose group in this study is less severe than that observed in previous studies. A BMD of 1604 mg/l (76 mg/kg-d) and a BMDL10 of 921 mg/l (44 mg/kg-d) were determined for chronic effects of NTO in male rats.

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Document Details

Document Type
Technical Report
Publication Date
Sep 16, 2019
Accession Number
AD1080765

Entities

People

  • Allison M. Narizzano
  • Emily M. Lent

Organizations

  • United States Army Center for Health Promotion and Preventive Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Body Weight
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Endocrine Glands
  • Health Services
  • Medical Personnel
  • Testes

Readers

  • Agricultural Chemistry/Soil Science
  • Toxicology/Environmental Toxicology