Bedside Amniotic Membrane Transplantation in SJS/TEN Patients in Twenty Minutes or Less
Abstract
Stevens-Johnson syndrome (SJS) and its more severe variant toxic epidermal necrolysis (TEN) are mucocutaneous hypersensitivity reactions that can give rise to significant ocular involvement and morbidity. If not recognized and treated early, conjunctival and corneal epithelial sloughing can lead to ocular surface cicatricial changes resulting in debilitating photophobia, dry eye, eye pain, and vision loss. Treatment is based on the severity of disease manifestation. Early amniotic membrane transplantation (AMT) has been recommended for the acute management of ocular surface disease. Previously, a pre-cut sheet of amniotic membrane was laid over the entire mucosal surface of the eye and the ends of the membrane were sutured to the eyelid skin. While efficacious, the procedure was lengthy and required additional sedation and operating room availability for patient comfort. Herein we present a faster, bedside technique for application of amniotic membrane to the ocular surface using cyanoacrylate glue. The glue polymerizes when it contacts wet surfaces making it an attractive adhesive agent for the moistened membrane. Tissue histotoxicity is also very minimal.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 02, 2019
- Accession Number
- AD1085487
Entities
People
- Aditya Mehta
- Anthony J. Johnson
- Donovan S. Reed
- Frederick E. Nelson
- G. B. Giles
- Robert Shelley
- Sheri L. Demartelaere
- Tatiania S. Zanganeh
- Timothy A. Soeken
Organizations
- 59th Medical Wing