Probing Response and Future Repair of Neural Function to Impact through a Nerve Integrated Tissue on a Chip (NITC) Platform and Mechanical Approach
Abstract
We worked on an experimental testing platform, called the "Nerve Integrated Tissue on a Chip (NITC)" to which we would apply mechanical force in a precisely controlled and measured system. Our focus was on measuring and modeling trauma-induced injuries to the network of neurons embedded in tissue for use in the diagnosis of innervated tissue injuries and with applications in developing future healing methods and treatment protocols. Through the experimental platform, our goals were to simulate the mechanical stimulation through the innervated tissues and relate this to neuron function in response to mechanical stimulation. We also are working toward predicting the level of neuronal injury, regenerative growth, and to understand how neuronal injuries are associated with injuries of tissues. We also would measure the healing of nervous system under a variety of manipulations, which may assist the therapy of disorders without the need for significant animal or human testing. Our expertise in the areas of mechanics, micromachining, micromolding and neurobiology was used to synthesize mimetic tissues with embedded neurons. In the future, finite element and mechanical analysis will be combined to develop a predictive model for improved healing and treatment of innervated tissue injuries, which will be very applicable to military personnel.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 04, 2016
- Accession Number
- AD1085656
Entities
People
- Philip Leduc
Organizations
- Carnegie Mellon University