The Development of Nitroxide-Containing Anti-Biofilm Agents
Abstract
Bacterial biofilms are a major problem in a number of environmental, industrial and medical applications. They cause significant risks to human health and present an enormous economic burden to society. An emerging strategy to combat biofilm formation and growth is to use small molecules that act through non-microbicidal mechanisms to inhibit and/or disperse biofilms. Nitroxides have shown potential in this regard, demonstrating both biofilm inhibition and dispersal properties. This project aims to develop novel nitroxide-based anti-biofilm agents by incorporating nitroxides into the structures of antibiotics and biocides and which can then be attached to polymer scaffolds using various tethering approaches. Our progress to date has involved the synthesis and characterization of hybrid compounds where nitroxides are linked to an antibiotic (ciprofloxacin), an anti-fungal agent (fluconazole) or a biocide (isothiazolone). The evaluation of the prepared compounds as anti-biofilm agents is on-going.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 05, 2019
- Accession Number
- AD1085924
Entities
People
- Kathryn Fairfull-Smith
Organizations
- Queensland University of Technology