Development of a Novel Segmental Bone Defect Construct
Abstract
This report contains the final summary of all project efforts conducted on the project Development of a Novel Segmental Bone DefectConstruct. The original project hypothesis was that one or more of the SIBLING (small integrin binding, N-linked glycoprotein) proteins isresponsible for recruiting cells for bone tissue repair and regeneration and their use in a tissue engineering scaffold will induce a natural,expedited wound healing response for segmental bone defects. This hypothesis was tested through the completion of four major tasks.Major Task #1 was to determine the SIBLING protein family member that facilitated the best MC3T3-E1 osteoblast-like cell attachment to amultifunctional polyampholyte hydrogel. In Major Task #2, the top performing SIBLING protein was evaluated in primary cell proliferation,differentiation, and penetration into the base case polyampholyte hydrogel. In Major Task #3, a family of polyampholyte hydrogels with arange of mechanical properties was developed. Finally, in Major Task #4 the primary cell proliferation, differentiation, and penetration intopolyampholyte hydrogels with a range of mechanical properties was evaluated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2019
- Accession Number
- AD1086081
Entities
People
- Matthew T. Bernards
Organizations
- University of Idaho