Neuroimaging Biomarker for Seizures

Abstract

The multi-site study will examine patients with epilepsy (ES) following head injury [i.e. posttraumatic epilepsy (PTE)] and posttraumatic Psychogenic Non-epileptic seizures (PNES) and will compare them to patients with traumatic brain injury (TBI) who do not have seizures. The research aims to investigate: 1. Differences in cerebral underpinnings of emotion and stress processing in PNES and PTE; 2. Neuroimaging biomarker of PTE and PNES that predicts treatment outcome in order to inform effective non-pharmacologic treatments for seizures; and 3. Evidence for a positive treatment response to the intervention (Cognitive Behavioral Therapy for Seizures (CBT-Sz), a manualized behavioral therapy program) that result in neuroplasticity. This study aims to enroll 264 participants (Veterans and civilians) divided over the sites: 88 with PNES, 88 with PTE, and 88 with TBI without PNES or PTE. Over the past year, we established multi-site infrastructure, obtained regulatory approval, started enrollment and preliminary data analysis.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1086183

Entities

People

  • Krista Tocco
  • William C. Jr Lafrance

Organizations

  • Providence VA Medical Center

Tags

DTIC Thesaurus Topics

  • Anxiety Disorders
  • Biomedical Research
  • Brain
  • Brain Injuries
  • Data Analysis
  • Diseases And Disorders
  • Epilepsy
  • Health Services
  • Medical Personnel
  • Neuroimaging
  • New England
  • Psychiatry
  • Rhode Island
  • Seizures
  • Traumatic Stress Disorder

Fields of Study

  • Medicine
  • Psychology

Readers

  • Canadian European Scientific Immigration and Epilepsy Clearance Studies
  • Neuroscience
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.