The Pathogenesis of Post-Traumatic Pulmonary Embolism: A Prospective Multi-Center Investigation by the CLOTT Study Group
Abstract
Venous thromboembolism, which includes both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and potentially mortal complication after injury in both civilian and military settings. To date, there are no methods that have been definitively demonstrated to prevent post-traumatic pulmonary embolism (PE) which carries a mortality of 11% and is the third leading cause of death following injury. PE is particularly common among combat casualties due to the prevalence of certain risk factors such as multiple amputations, traumatic brain injury, the need for transfusions, and prolonged immobilization during evacuation. In Year 2, all sites were approved by local IRBs and HRPO for CLOTT Part 1 (17 sites) and CLOTT Part 2 (5 sites). All sites are enrolling participants. Due to delays in approvals, sites require additional time to meet enrollment targets. A 12-month extension without funds was requested and approved. All sites will continue to recruit subjects in the third project year. There are no significant findings to report at this time.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2019
- Accession Number
- AD1086216
Entities
People
- Mary Knudson
- Michelle A. Price