Fusion Genes Predict Prostate Cancer Recurrence
Abstract
Most prostate cancers are indolent, and may not require clinical intervention. Only a small fraction of cases progress to metastatic disease if not treated. Prediction of the clinical outcomes of prostate cancer remains a challenge. Recently, we discovered a panel of 8 fusion genes that occurred in aggressive prostate cancer. The presence of these fusion genes correlates 91 percent chance of recurrence of prostate cancer. In order to make the fusion gene test clinically ready as a predictor, we have modified to test into a semi-quantitative Taqman QRT-PCR. The tests were performed in CLIA certified lab. Four hundred and sixty samples of prostate cancers were collected. Prostate cancer cells were microdissected. Taqman QRT-PCRs were performed on these samples. Significant numbers of samples were found positive for some of these fusion genes. In addition, we have analyzed 150 samples from Stanford University and 155 samples from University of Wisconsin Madison. A training model has been constructed. We are in the process to apply the model to testing sets.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2019
- Accession Number
- AD1086222
Entities
People
- Jianhua Luo
Organizations
- University of Pittsburgh