Optimization of Delayed Tolerance Induction in Swine: A Clinically-Relevant Protocol for Immunosuppression-Free Vascularized Composite Allotransplantation

Abstract

Vascularized composite allotransplantation (VCA) has emerged as a viable option for restoring form and function in patients with devastating soft tissue defects. To date, 44 faces and 120 hand/upper extremity transplants have been performed worldwide, with promising short- to intermediate-term functional and immunological outcomes. Nevertheless, the requirement for long- term immunosuppressive therapy to maintain the allograft increases the risk of related side effects such as infections, metabolic complications or even malignancies.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1086247

Entities

People

  • Curtis L. Cetrulo, Jr

Organizations

  • Massachusetts General Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Allografts
  • Biomedical Research
  • Bone Marrow
  • Cells
  • Composite Materials
  • Department Of Defense
  • Diseases And Disorders
  • Health Services
  • Lymphocytes
  • Medical Personnel
  • Professional Development
  • Side Effects
  • Surgery
  • Tissue Donors
  • Transplants
  • Upper Extremity

Fields of Study

  • Medicine

Readers

  • Neuroscience
  • Oncology
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology