Yeast Surface Display Approaches for Engineering Stabilized Viral Fusion Protein Subunit Vaccines

Abstract

This research proposal focuses on the development of a novel library screening approach to engineering highly stabilized subunit vaccine candidates for major pathogens within the paramyxovirus family. The research addresses the PRMRP topic areas related to vaccine development for infectious pathogens as well as addressing the topic concerning emergent viruses. The paramyxoviruses encompass many pathogens that cause disease in humans and this proposal focuses on four viruses that fall into two subclasses within the broader family,respiratory syncytial virus (RSV), human metapneumovirus (HMPV), Nipah virus (NiV) and HendraVirus (HeV).

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2019
Accession Number
AD1086275

Entities

People

  • Theodore Jardetzky

Organizations

  • Stanford University

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Biomedical Research
  • Cells
  • Department Of Defense
  • Diseases And Disorders
  • Dna Sequence Analysis
  • Engineering
  • Epithelial Cells
  • Fungi
  • Infectious Diseases
  • Information Operations
  • Law
  • Maryland
  • Proteins
  • Universities
  • Vaccines

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Research Science/Academic Research
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology