Hypothermia for Patients Requiring Evacuation of Subdural Hematoma: Effect on Spreading Depolarizations

Abstract

This report describes Year 2 progress in clinical studies to determine the impact of temperature management on spreading depolarizations (SD) and outcomes in severe traumatic brain injury (TBI). After DSMB closure of the proposed prospective trial, revised statements of work and budgets were prepared, and through several iterations, resulted in execution of a modified contract in the 3rd quarter to address the research question using existing clinical databases from the W81XWH-08-2-0016 (Objective 1) and TRACK-TBI (NIH U01; Objective2) studies. New and revised subaward contracts, ethical approvals, and other permissions to conduct these studies were obtained. Studies were inventoried, identifying sample sizes of n=138 ICU-admit patient with SD data and n=1083 without SD data. Preparation of databases, including hourly nursing chart values, for statistical analysis was initiated, including data extraction, organization, and cleaning. Custom programming to import, query, and export data was initiated. Study teams were organized with exploration of initial statistical approaches.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1086362

Entities

People

  • Jed A Hartings

Organizations

  • University of Cincinnati

Tags

DTIC Thesaurus Topics

  • Brain Injuries
  • Computer Programming
  • Contracts
  • Craniocerebral Trauma
  • Data Curation
  • Data Science
  • Databases
  • Department Of Defense
  • Depolarization
  • Evacuation
  • Extraction
  • Hypothermia
  • Information Science
  • Management Personnel
  • Medical Personnel
  • Organizational Structure
  • Temperature Control

Readers

  • Cardiovascular Physiology
  • Clinical Trial Research.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.