The Imprint of Psychogenic Nonepileptic Seizures on the Brain: A New Model and Imaging Biomarker
Abstract
The goal of the project is to obtain evidence to support a new mechanism that assumes that PNES are caused by a predisposition for enhanced synchronization/overshooting recruitment of brain regions involved in emotion control/processing of traumatic/stressful experiences. By assuming such a predisposition, the project implicitly assumes that PNES have a specific biological underpinning. The first year of the project was spent on finalizing questionnaires and report forms, obtaining IRB approval from participating institutions, implementation of the imaging protocol, processing pipelines and hiring and training of research personnel. The project was allowed to enroll patients from 05/18 on. The second year was spent on obtaining permission to add UCSF as additional referral site, analyzing incoming data, modifying the pipeline used to generate simulated data to simulate/characterize the fMRI signature of the PNES imprint and trying to maximize referral of suitable patients for the project.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2019
- Accession Number
- AD1086396
Entities
People
- Susanne G Mueller