A Novel Visually Graded CT Biomarker of Preinjury Brain Structure to Improve Prediction of Cognitive Decline After Mild Traumatic Brain Injury
Abstract
Mild traumatic brain injury (mTBI) is a signature injury of modern warfare and affects an estimated 42 million people worldwide each year. MTBI may lead to chronic cognitive problems (in memory and thinking ability) in up to half of patients. Even more concerning is that mTBI may lead to progressive cognitive decline and eventual Alzheimers dementia (AD) and AD related disorders (ADRD),increasing risk by up to 3-fold. There are currently no practical tools to accurately predict who will suffer from chronic or progressive cognitive consequences of mTBI and who will recover uneventfully. Our project will directly address the overarching challenge of the need for biomarkers and tools to prognose cognitive decline and subsequent progression to AD/ADRD after mTBI. Scope: We are conducting a 3-year project that will cost-efficiently harness existing data from more than 1,260 adults age 16 years and older presenting to 18 trauma centers across the U.S. within 24 hours of mTBI who participated in the DoD/NIH-funded Transforming Research And Clinical Knowledge in TBI (TRACK-TBI) study.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2019
- Accession Number
- AD1086509
Entities
People
- Raquel C Gardner
Organizations
- Northern California Institute for Research and Education