Developing New Therapeutic Strategies for Malignant Peripheral Nerve Sheath Tumor by Interrupting Immunologic Tolerance

Abstract

Based on recent data from us and others using human clinical MPNST specimens, we seek validation in mouse models of a novel treatment paradigm that could lead to new clinical trials. Our approach is based on stimulating antitumor immunity using oncolytic virus infections combined with inhibitors of immunosuppression, including those targeting TGFbeta (both directly and indirectly, through the Janus kinase inhibitor Ruxolitinb) and T cell checkpoints.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2019
Accession Number
AD1086513

Entities

People

  • Timothy Cripe

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DTIC Thesaurus Topics

  • Biomedical Research
  • Cell Line
  • Cells
  • Cytokines
  • Department Of Defense
  • Gene Expression
  • Governments
  • Humanities
  • Infection
  • Inhibition
  • Inhibitors
  • Intellectual Property
  • Lymphocytes
  • Medical Personnel
  • Patent Applications
  • Professional Development
  • Proteins

Fields of Study

  • Biology
  • Medicine

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  • Molecular and Cellular Biology
  • Oncology