Early Detection of Alzheimer's Disease by Relayed NOE CEST MRI
Abstract
Alzheimer's disease (AD) is the most common cause of dementia, and currently, more than 5 million people have AD in the US alone. The accumulation of neuritic plaques comprised of amyloid-beta peptides and neurofibrillary tangles (NFT) of hyperphosphorylated tau are the major histopathological hallmarks of Alzheimer's disease. Therefore, the detection of the aggregated proteins involved in AD is expected to be a promising strategy for the early diagnosis of the disease. We recently developed a new chemical exchange saturation transfer (CEST) technique, UTE-CEST, which is able to obtain high-resolution rNOE-CEST MRI insensitive to motion. We hypothesize that the rNOE-CEST signal detected by CEST-UTE on AD mouse is associated with the amyloid-beta peptides and NFT accumulation due to the line broadening of amide and aliphatic proton signal in proteins introduced by protein aggregation. The optimized UTE-CEST method will be applied on two AD mouse models to verify that the technique is sensitive enough to detect the early protein aggregation seen in AD disease. Upon the successful completion of this proposal, we anticipate developing a new clinic-ready MRI technique that detect and evaluate the AD associated protein aggregation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2019
- Accession Number
- AD1086537
Entities
People
- Jiadi Xu
Organizations
- Kennedy Krieger Institute