TRACK-TBI Precision Medicine - Pathomechanistic Classification of Traumatic Brain Injury: The Bridge to Targeted Therapies

Abstract

TRACK-TBI Precision Medicine utilizes the rich TRACK-TBI dataset to validate biomarkers of diffuse axonal injury (DAI), microvascular injury (MVI), and neuro-inflammation using advanced blood-based assay platforms and MRI sequences. The project will validate early and ultra-early blood-based and imaging biomarkers of DAI, MVI, and neuro-inflammation and will conduct a multicenter, double-blind, placebo-controlled exploratory clinical trial comparing the impact of cyclosporine A on blood-based and imaging biomarkers of DAI and neuro-inflammation in moderate/severe TBI patients.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1086557

Entities

People

  • Amy J. Markowitz
  • Brian Fabian
  • Geoffrey T. Manley

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Brain Injuries
  • California
  • Cardiovascular Physiological Phenomena
  • Diseases And Disorders
  • Genetics
  • Health Services
  • Mass Spectrometry
  • Medical Personnel
  • Neuroimaging
  • Proteins
  • Vascular System Injuries

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Neurotrauma and Rehabilitation Medicine.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.