Individualized Medicine in a Gyrencephalic Model of TBI Polytrauma Through the Continuum of Care

Abstract

Advancements in combat casualty care for traumatic brain injury (TBI) have greatly improved mortality and morbidity rates during recent armed conflicts. Damage control resuscitation, delayed wound closure, tourniquets, and rapid evacuation for damage control surgery are examples of those observations contributing to improved care. Military casualties face numerous complications to their care that are uncommon in civilian medical practice, including the mode, multiplicity, and severity of injuries, combat- related limitations on the modalities of acute care, potentially prolonged delay to definitive care, and the possibility of prolonged aeromedical evacuation with its attendant unique environmental stressors. However, most treatment strategies are based on standard protocols which lack the subtlety to account for patient specific differences in response to therapy, thus resulting in missed opportunities for improved outcomes at the individual patient level.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2019
Accession Number
AD1086608

Entities

People

  • Randy Bell

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Brain Injuries
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Combat Casualty Care
  • Gene Expression
  • Growth Factors
  • Hemorrhagic Shock
  • Medical Personnel
  • Molecules
  • Neuroimaging
  • Peptide Growth Factors
  • Peptides
  • Pilot Studies
  • Professional Development
  • Proteins

Fields of Study

  • Medicine

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Systems Analysis and Design
  • Trauma or Military Medicine