HIOC Derivatives for the Treatment of Trauma-Induced Vision Loss
Abstract
Pressure waves due to explosions can damage the neurons of the eye and visual centers in the brain, leading to visual function loss. There are currently few treatments for such injuries that can be deployed rapidly in the field to mitigate such damage. We are developing small molecule activators of TrkB, the cognate receptor for brain-derived neurotrophic factor (BDNF), which cross the blood/retina and blood/brain barriers. In preliminary studies, we have shown that our lead compound, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3- carboxamide (HIOC), protects against blast-induced retinal degeneration and vision loss when injected within three hours of trauma. In the first year of this project, we have focused on the development HIOC derivatives that have the potential to be more potent and efficacious than the parent compound. Thus far, 16 derivatives have been synthesized and chemically characterized.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2019
- Accession Number
- AD1086697
Entities
People
- Frank E. Mcdonald
- P. M. Iuvone
Organizations
- Emory University