Acute and Delayed Systemic Treatment with Cannabinoid Receptor 2 Agonists to Prevent or Treat/Reverse Osteoporosis in a Mouse Model of SCI

Abstract

The overall goal of this project is to determine whether a selective agonist for the Cannabinoid-2 receptor, when systemically delivered, can prevent the onset of osteoporosis in mice when delivered during the acute phase of spinal cord injury or restore bone density when delivery is delayed until the late, chronic period of injury. Dr. Grill, the PI of this project passed away at the very end and did not complete the work. Dr. Grayson and her assembled team has asked to complete the work and publish the findings. Here we lay out the work that was completed by Dr. Grill and the outline of a plan to complete this work by replacement PI, Bernadette Grayson.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2018
Accession Number
AD1087094

Entities

People

  • Bernadette E Grayson

Organizations

  • University of Mississippi Medical Center

Tags

DTIC Thesaurus Topics

  • Biological Staining And Labeling
  • Biomedical Research
  • Bone Marrow
  • Bones
  • Cell Physiological Processes
  • Department Of Defense
  • Histology
  • Medical Personnel
  • Musculoskeletal Physiology
  • Osteoblasts
  • Osteoporosis
  • Peptides
  • Spinal Cord
  • Spinal Injuries
  • Students
  • Surgery
  • United States

Fields of Study

  • Biology
  • Medicine

Readers

  • Clinical Trial Research.
  • Neurotrauma and Rehabilitation Medicine.