Investigating the Role of TGIF in Beta Cell Function and Diabetes

Abstract

Diabetes mellitus is a devastating metabolic disease characterized by hyperglycemia that can occur through distinct mechanisms, such as islet beta-cell destruction, beta-cell failure, and insulin resistance in peripheral tissues. The increasing prevalence of diabetes also affects the military personnel. Several genes associated with diabetes have been identified in genome wide association studies, but their genetic validation as causative factors remains to be demonstrated experimentally. In this grant proposal, we focused on one of these genes, TGIF, whose conditional overexpression in the pancreatic tissue led to severe hyperglycemia and diabetes. We proposed mechanistic experiments to investigate how TGIF1 induces diabetes. Our preliminary findings strongly suggest that TGIF overexpression in the pancreatic tissue induced beta-cells, providing a mechanism by which TGIF drives diabetes.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2018
Accession Number
AD1087127

Entities

People

  • Azeddine Atf
  • Yin-Yuan Mo

Organizations

  • University of Mississippi Medical Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biological Processes
  • Biomedical Research
  • Cells
  • Department Of Defense
  • Diseases And Disorders
  • Genes
  • Glucose Metabolism Disorders
  • Histology
  • Information Operations
  • Insulin
  • Medical Personnel
  • Metabolic Diseases
  • Military Personnel
  • Pancreas
  • Tissues
  • Transcription Factors
  • Universities

Fields of Study

  • Biology

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Molecular and Cellular Biology

Technology Areas

  • Biotechnology