Age-Independent Immunosenescence: An Antigen-Activated, Sexually Dimorphic Program Predicts Inflammation of Aging and HIV-1 Susceptibility
Abstract
In epidemiologic, immunologic, and genetic analyses of 16,217 people, 279 non-human primates, and 334 mice, we identified age-independent immunosenescence (AIIS), a process concurrent with but distinct from age-dependent immunosenescence (ADIS). AIIS is the consequence of an evolutionarily conserved response to antigenic stimulation characterized by unrestrained expansion of CD8+ relative to CD4+ T-cells. At any age, AIIS correlates with lower immunologic integrity, and its immunologic hallmarks (e.g., CD28CD8+ T-cells) have been misattributed to ADIS.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 04, 2020
- Accession Number
- AD1087154
Entities
People
- Alisha M. Smith
- Andrew Carrillo
- Anne P. Branum
- Brian K. Agan
- Christopher King
- Davey M. Smith
- Douglas D. Richman
- Edoardo Fiorillo
- Edwina J Wright
- Elizabeth A. Walter
- Fabio Jimenez
- Francesco Cucca
- Francis A. Plummer
- Grace C. Lee
- Guido Silvestri
- Hong-yi Zheng
- Jason F Okilicz
- Jennifer M Lund
- Joshua Kimani
- Justin A. Meunier
- Kathryn J. Wood
- Keith R. Fowke
- Lavanya Pandranki
- Lyle R. Mckinnon
- Maristella Steri
- Mark T Heise
- Martin T Ferris
- Matthew J Bottomley
- Muthu S. Manoharan
- Nathan Harper
- Nigel Garrett
- Nu Zhang
- Paul N. Harden
- Robert A Clark
- Robert Root-Bernstein
- Scott Letendre
- Sunil K. Ahuja
- Susan J Little
- T. B. Ball
- Tomas M Ferguson
- Valeria Orr
- Weijing He
- Yong-Tang Zheng
Organizations
- 59th Medical Wing