Grandparental Exposures and Risk of Autism in the Third Generation
Abstract
In the second year, we identified 21,772 Child Health and Development Studies grandchildren (F2) by linking to the California Birth Records, which was slightly greater than our original estimate of 20,000. Using address history files, we verified 18,371 CHDS grandchildren births. We were able to support our matching results by using self-reported child bearing (births of F2) data collected from a subset of our cohort second generation (F1) women. This comparison supported the validity of our matching efforts to identify our CHDS F2. By linking the verified births to the California Department of Developmental Services records we have successfully identified 116 autism cases in our cohort which exceeds our initial estimate of 72. We will use a prospective study of 18,371 CHDS grandchildren (F2) with 116 autism cases to explore the effect of grandparental (F0) exposures. This will be the first study of its kind in the United States, linking three generations from the 1960's through the 2010's and will establish a platform for studying germline exposures and risk of autism.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2019
- Accession Number
- AD1087155
Entities
People
- Barbara A Cohn
- Nickilou Krigbaum
- Piera Cirillo
Organizations
- Public Health Institute