CD8-CD4 Disequilibrium Predicts The Risk Continuum Of HIV Acquisition, AIDS, and Muted Immunologic Reconstitution Despite Early Therapy
Abstract
Many younger, HIV+ persons receiving virally suppressive antiretroviral therapy (ART) remain immunologically impaired and share certain disease risks in common with older, HIV persons. Our results from HIV (n=9,827) and HIV+ (n=6,336) cohorts suggest that this commonality relates to a distinct immunosuppression-mediating program age-independent immunosenescence (AIIS) activated in response to repeated antigenic stimuli associated with aging, risk factors for HIV, and HIV infection. AIIS and advanced AIIS indicate distinct grades of immunosuppression, quantifiable via novel CD8-CD4 equilibrium metrics that track degree of disequilibrium between CD8+ and CD4+ T-cell levels. AIIS may precede and contribute to the likelihood of HIV acquisition. Advanced AIIS, present in nearly 40% of patients during primary/early HIV infection, is genetically determined and predicts AIDS.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 04, 2020
- Accession Number
- AD1087165
Entities
People
- Alisha M. Smith
- Andrew Carillo
- Anne P. Branum
- Brian K. Agan
- Christopher King
- Davey M. Smith
- Douglas D. Richman
- Edoardo Fiorillo
- Edwina J Wright
- Elizabeth A. Walter
- Fabio Jimenez
- Francesco Cucca
- Francis A. Plummer
- Grace C. Lee
- Jason F. Okulicz
- Joshua Kimani
- Justin A. Meunier
- Keith R. Fowke
- Kristen R. Canady
- Lavanya Pandranki
- Lise Werner
- Lyle R. Mckinnon
- Maristella Steri
- Matthew J Bottomley
- Muthu S. Manoharan
- Nathan Harper
- Nigel Garrett
- Nu Zhang
- Robert A Clark
- Robert Root-Bernstein
- Salim Abdool Karim
- Sara Gianella-weibel
- Scott Letendre
- Sunil K. Ahuja
- Susan J Little
- T. B. Ball
- Tomas M Ferguson
- Valeria Orr
- Weijing He
Organizations
- 59th Medical Wing