Emerging Infectious Disease Diagnostic via Novel Optoelectronic Halo Effect

Abstract

Forward deployed military units have a critical need for a robust, low cost, easy to use diagnostic system providing realtime, quantitative, and multiplex capability of identifying biomarkers for infectious disease, including tuberculosis. This is a project to develop a new diagnostic device for detection of the tuberculosis biomarker lipoarabinomannan based on a novel "plasmonic halo" effect. In the initial stage, various halo nanodevices using a set of chosen metals and dielectrics were fabricated, and their plasmonicoptical response / sensitivity characterized. A major finding was that bullseye halos are significantly more responsive than standard devices, with sensitivities above 100 nm/RIU (refractive index unit). Moreover, incorporation of inorganic quantum dots has shown promise for enhancing sensitivity further.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2019
Accession Number
AD1087178

Entities

People

  • Michael J. Naughton

Organizations

  • Boston College

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical
  • Sensors

DTIC Thesaurus Topics

  • Chemistry
  • Crystal Structure
  • Detection
  • Electromagnetic Fields
  • Health Services
  • Infectious Diseases
  • Magnetic Fields
  • Materials Laboratories
  • Materials Processing
  • Materials Science
  • Nanotechnology
  • Optics
  • Refractive Index
  • Solar Cells
  • Surface Plasmon Resonance
  • Three Dimensional
  • Two Dimensional

Fields of Study

  • Physics

Readers

  • Nanoscale Plasmonic Nanotechnology
  • Oncology and Biomarker-Based Cancer Detection.
  • Psychometric Testing or Psychological Assessment.

Technology Areas

  • Microelectronics
  • Microelectronics - Microelectromechanical Systems
  • Quantum Computing