The Role of the Gut Microbiome in Colorectal Cancer

Abstract

Inflammatory bowel disease (IBD) is a chronic condition of the gastrointestinal tract that predisposes individuals to develop CRC. Chronic inflammation is one of the key hallmarks of cancer and dysbiosis of the gut microbiome is proposed to promote CRC. The prevalence of IBD has increased 2- to 3-fold among veterans. The objective of this proposal is to utilize Il10-/- mice, a model of human IBD, together with Stat2-/- mice, which are more resistant to CRC to: 1) identify unique microbial communities in the gut and 2) metabolites of bacterial and host origin that mediate anti-inflammatory and antitumor effects to control inflammation and drastically reduce the risk of CRC development.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2019
Accession Number
AD1087183

Entities

People

  • Ana Gamero

Organizations

  • Temple University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Colon Cancer
  • Diseases And Disorders
  • Education
  • Gastrointestinal Tract
  • Genetics
  • Governments
  • Gut Microbiome
  • Humanities
  • Local Governments
  • Medical Personnel
  • Microbiomes
  • Neoplasms
  • Professional Development
  • Students
  • Training

Fields of Study

  • Biology

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Immunology and Pathology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech