Application of Combined Cardioprotective Agents to Preserve Organ Function and Improve Survival During Experimental Hemorrhagic Shock
Abstract
We investigated the effects of hypothermia treatment alone and in combination with experimental bilateral lower limb remote ischemic preconditioning (RIPC) in rats undergoing experimental hemorrhagic shock. Previously we showed that RIPC alone improved survival. In the setting of hypothermia alone, 4 of 15 (26.7 percent) rats in the control group and 11 of 16 (68.8 percent; p = 0.032) rats in the hypothermia group survived at 6 weeks. pO2 remained essential normal and levels of potassium, chloride, and lactate were lower in hypothermia group. In the combination study, 1 of 10 (10 percent) rats in the control group and 7 of 11 (63.6 percent; p = 0.024) rats in the hypothermia plus RIPC group survived at 6 weeks. The neutrophil-to-lymphocyte ratio (NLR) was significantly lower in Hypothermia plus RIPC. NLR has been reported to be strongly associated with early mortality in patients with severe hemorrhage and represents disease severity. We concluded that hypothermia alone and combination with RIPC significantly improved long term survival in rats subjected to hemorrhagic shock. Hypothermia and RIPC did not show survival rates greater than hypothermia alone.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2019
- Accession Number
- AD1087191
Entities
People
- Robert A Kloner
Organizations
- Huntington Medical Research Institutes