Statins Prevent Pancreatic Diseases Through Mitophagy Activation

Abstract

This proposal addressing FY16 PRMRP topic area Pancreatitis is designed to determine the mechanisms of statin mediated protection from pancreatitis, an observation recently reported using a retrospective cohort analysis of large clinical datasets. Prevention of pancreatitis, especially cases that progress to recurrent acute and chronic pancreatitis is of high relevance because there is no treatment for these disorders and because the progression is associated with an extremely high risk of pancreatic cancer, one of the most lethal human cancers.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2019
Accession Number
AD1087216

Entities

People

  • Stephen J Pandol

Organizations

  • Cedars-Sinai Medical Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acinar Cells
  • Autophagy
  • Biological Processes
  • Biomedical Research
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Cytoplasmic Vesicles
  • Diseases And Disorders
  • Electron Microscopy
  • Health Care
  • Health Services
  • Ischemia
  • Medical Personnel
  • Pancreatic Diseases
  • Proteins
  • Vascular Diseases

Fields of Study

  • Medicine

Readers

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