Exploration of a Novel Molecular Brake for Remyelination in MS

Abstract

This research study explores ways to enhance myelin repair. The premise upon which the research is founded is that the signaling molecule, Csk, acts as an endogenous suppressor of myelin repair. We have been exploring the possibility that the AMPK pathway is key component of the Csk-induced brake to myelin repair. We have activated AMPK signaling following myelin damage and preliminary indications are that AMPK activation promotes myelin health and/or repair. We also found that AMPK activation enhances oligodendrocyte differentiation from oligodendrocyte progenitor cells using rodent cultures. We are currently exploring other aspects of the oligodendrocyte and myelin phenotypes in both gain- and loss-of-function modes of AMPK signaling, as well as optimizing our strategies for Csk loss in vivo and in vitro.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2019
Accession Number
AD1087367

Entities

People

  • Ashley Volz
  • Holly Colognato
  • Mohaniall Narine

Organizations

  • State University of New York

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Brain
  • Cells
  • Demyelinating Diseases
  • Department Of Defense
  • Diseases And Disorders
  • Gene Expression
  • Genes
  • Maryland
  • Medical Personnel
  • Multiple Sclerosis
  • Neuroglia
  • Neurosciences
  • New York
  • Students
  • Training
  • United States

Readers

  • Geochemistry
  • Immunology and Pathology
  • Neuroscience