Investigation of Metabolism in Hypertrophic Cardiomyopathy

Abstract

In Year 1, we compiled metabolite profiles from heart tissue in 2 mouse models of hypertrophic cardiomyopathy (HCM) in the pre-clinical stage of disease (5 week old mice). Using GC-TOF, only 1 metabolite was significantly lower in MyHC mutants compared to littermate controls at baseline. In contrast, we found differences in levels of 13 metabolites in TnT mutants when compared to littermate-controls. Taken together, our results suggest allele-specific differences in metabolic remodeling at the preclinical stage of HCM in mouse models.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2019
Accession Number
AD1087482

Entities

People

  • Maria R. Abraham

Organizations

  • University of California Regents

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Buildings And Structures
  • California
  • Cardiomyopathies
  • Communities
  • Department Of Defense
  • Discriminant Analysis
  • Diseases And Disorders
  • Law
  • Metabolism
  • Metabolites
  • Metabolomics
  • Mutations
  • Patent Applications
  • Professional Development
  • Research Facilities
  • Training

Fields of Study

  • Biology
  • Medicine

Readers

  • Agricultural Chemistry/Soil Science
  • Toxicology/Environmental Toxicology
  • Trauma Surgery or Emergency Medicine.