Generation of a Mouse Model to Investigate IL-6 Trans-Signaling in ALS
Abstract
1) IL6 transsignaling plays a potential protective role for motoneurons in the periphery, while later when extracellular levels of IL6 increase with increased muscle atrophy and decreased lung function, transsignaling promotes a breakdown in the blood brain barrier that fosters IL6 transsignaling in the CNS that can promote disease progressions through glial activation. 2) Individuals with increased levels of soluble receptor such as those with enhanced shedding due to IL6R polymorphism will be more susceptible to IL6 transsignaling and will have faster disease progression. 3) Blocking the effects of IL6 transsignaling will reduce disease progression rates and disease severity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2019
- Accession Number
- AD1087547
Entities
People
- Gregory Hawkins
Organizations
- Wake Forest University