Using Multimodal Imaging to Examine the Neural Mechanisms of an Integrative Exercise Program for Individuals with Dementia

Abstract

The goal of this project is to investigate whether participation in the Preventing Loss of Independence through Exercise (PLI) program for 4 months will result in neurobiological changes that improve cognitive function, leading to improvements in physical function and quality of life (QOL). We will estimate the impact of PLI on brain atrophy rates, Default Mode Network (DMN) functional connectivity, and cerebral perfusion and determine if improvements in cognition, function, and QOL are associated with changes in brain volume, DMN functional connectivity, and cerebral perfusion in individuals who participated in PLI.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2019
Accession Number
AD1087635

Entities

People

  • Linda L Chao

Organizations

  • Northern California Institute for Research and Education

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Biomedical Research
  • Cognition
  • Cognitive Impairment
  • Dementia
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Governments
  • Institutional Review Board
  • Local Governments
  • Medical Personnel
  • Patent Applications
  • Perfusion
  • Professional Development
  • Quality Of Life
  • Training

Readers

  • Computer Science.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.