Real-Time Detection of Cellular Respiratory Biomarkers of Early-Stage Infections Using Terahertz Sensing
Abstract
Early detection and prevention of respiratory infections is a critical mission of military and civilian medical facilities. For example, adenoviruses are a major cause of acute respiratory illness in the military. The hypothesis that different types of cells produce unique profiles of respiratory chemicals (gaseous biomarkers) is substantiated by apparent differences in cell-specific metabolic biochemistry. The research team comprised of Drs. Ivan Medvedev (WSU-Physics), Katherine Excoffon (WSU-Biology), and Jennifer Martin (AFRL) is studying the variability of respiratory chemical profiles for a variety of cellular species, as well as a range of metabolic, homeostatic, and infectious conditions. The analysis is done using THz chemical sensing facility at WSU and Gas Chromatography-Mass Spectrometry (GC-MS) facility at AFRL. We are studying variability of respiration associated with viral infections (such as adenovirus). We are studying the effects of variability of cellular metabolism in response to varying concentrations of glucose, insulin, melatonin, and cortisol intended to simulate a range of cellular stress conditions. An exhaustive range of respiratory biomarkers from cellular models will be collected to create biomarker libraries and investigate the feasibility of using this information for pre-symptomatic detection of related pathologies, unadulterated by competing bio-processes in human body.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 31, 2019
- Accession Number
- AD1087660
Entities
People
- Ivan R. Medvedev
- Jennifer Martin
- Katherine Excoffon
Organizations
- Wright State University